What is the role of the immunoglobulin superfamily (IgSF) in cancer?
The immunoglobulin superfamily (IgSF) comprises a diverse group of CAMs involved in cell-cell adhesion and immune responses. Members like ICAM-1 and VCAM-1 are often upregulated in cancer and can promote tumor cell adhesion to endothelial cells, aiding in metastasis. Additionally, they can modulate the immune microenvironment, influencing tumor immune evasion.
