What is the Role of the Tumor Microenvironment in Vascularization?
The tumor microenvironment (TME) includes various cell types such as fibroblasts, immune cells, and endothelial cells, all of which can influence tumor angiogenesis. Fibroblasts, for instance, can secrete growth factors that promote angiogenesis, while immune cells can both positively and negatively regulate this process through the release of cytokines and other signaling molecules.
