What Role Does Hypoxia Play in Tumor Vascularization?
Hypoxia, a condition characterized by low oxygen levels, is a significant trigger for angiogenesis in tumors. When tumor cells experience hypoxia, they stabilize Hypoxia-Inducible Factor 1-alpha (HIF-1α), which in turn upregulates the expression of VEGF and other angiogenic factors. This response helps the tumor to adapt to the low oxygen environment by promoting the formation of new blood vessels.
