TNFR2 is one of the two receptors for Tumor Necrosis Factor (TNF), a cytokine involved in systemic inflammation. Unlike its counterpart, TNFR1, which is ubiquitously expressed, TNFR2 is predominantly found on regulatory T cells (Tregs), endothelial cells, and certain tumor cells. The receptor mediates TNF's immune-modulating effects, contributing to both pro-inflammatory and immunosuppressive outcomes.
