Toll-Like Receptor 4 (TLR4) is a protein that plays a crucial role in the immune system by recognizing pathogen-associated molecular patterns (PAMPs) and initiating an immune response. TLR4 is part of the larger Toll-Like Receptor family, which is essential for the body's defense mechanisms. Specifically, TLR4 is known for recognizing lipopolysaccharides (LPS) found on the outer membrane of Gram-negative bacteria.