X Box Binding Protein 1 (XBP1) is a transcription factor that plays a crucial role in the unfolded protein response (UPR), a cellular stress response related to the endoplasmic reticulum (ER). XBP1 is essential for the proper functioning of the ER, which is responsible for protein folding, maturation, and transport. Under stress conditions, such as hypoxia or nutrient deprivation, XBP1 is activated to help cells adapt and survive.