What Mechanisms Do Latent Viruses Use to Promote Cancer?
Latent viruses can contribute to oncogenesis through several mechanisms:
Genomic Integration: Some viruses integrate their genetic material into the host genome. This can disrupt normal cellular regulatory pathways, leading to uncontrolled cell division. Oncoprotein Production: Latent viruses can express proteins that interfere with tumor suppressor pathways, such as p53 and Rb, promoting cell survival and proliferation. Chronic Inflammation: Viral latency often leads to chronic inflammation, creating a microenvironment conducive to cancer development.
