PLC contributes to tumorigenesis through multiple mechanisms: 1. Signal Transduction: PLC activates downstream signaling pathways such as the Protein Kinase C (PKC) pathway, which can promote cell growth and survival. 2. Calcium Signaling: IP3 generated by PLC activity releases calcium from intracellular stores, influencing various cellular functions including migration and invasion. 3. Gene Expression: DAG activates PKC, which in turn can modulate the activity of transcription factors like AP-1 and NF-κB, leading to changes in gene expression that favor tumorigenesis.
