Which PLC Isoforms Are Most Commonly Involved in Cancer?
There are several isoforms of PLC, but PLCγ, PLCβ, and PLCδ are often associated with cancer. For example, PLCγ1 is found to be overexpressed in breast cancer and is linked to poor prognosis. PLCβ isoforms are frequently altered in colorectal cancer, while PLCδ mutations have been identified in melanoma.
