What new insights have been gained from cancer genomics?
Cancer genomics continues to provide critical insights into the molecular mechanisms driving cancer. Recent large-scale genomic studies have identified novel mutations and gene fusions that contribute to cancer development and progression. These findings have led to the identification of new therapeutic targets and the development of precision medicine approaches. For example, the discovery of specific mutations in the BRCA1 and BRCA2 genes has led to the use of PARP inhibitors in ovarian and breast cancer treatment. Additionally, the study of tumor heterogeneity has revealed that even within a single tumor, there can be multiple genetically distinct subclones, impacting treatment resistance and disease recurrence.
