What Role Do Physicochemical Properties Play in Drug Resistance?
Drug resistance in cancer treatment is a major challenge, often linked to the physicochemical properties of drugs. For instance, if a drug has poor cell permeability due to its high hydrophilicity, cancer cells may develop mechanisms to pump the drug out before it reaches its target. Similarly, instability in the physiological environment can lead to rapid degradation of the drug, rendering it ineffective. Adjusting these properties can help overcome resistance mechanisms.
