What Role Does Hypoxia Play in Cancer Progression?
Hypoxia, or low oxygen levels, is a common feature of rapidly growing tumors. It can lead to the stabilization of hypoxia-inducible factors (HIFs), which promote angiogenesis, metabolic adaptation, and survival pathways. Hypoxia can also drive genomic instability and select for more aggressive cancer cell clones, contributing to tumor progression and resistance to therapy.
