What Role Does PKM2 Play in Tumor Growth and Survival?
PKM2 supports tumor growth and survival through various mechanisms. Its ability to toggle between active and less active forms enables cancer cells to adapt to changing metabolic needs. By promoting the accumulation of glycolytic intermediates, PKM2 aids in the synthesis of nucleotides, amino acids, and lipids necessary for rapid cell division. Furthermore, PKM2 has non-metabolic functions, including roles in gene transcription and the regulation of apoptosis and autophagy.
