The extracellular matrix (ECM) is a collection of extracellular molecules secreted by cells that provide structural and biochemical support to the surrounding cells. It plays a pivotal role in the TME by:
1. Providing Structural Integrity: The ECM helps maintain the shape and structure of the tissue. 2. Facilitating Cell Signaling: The ECM contains growth factors and other signaling molecules that can influence cell behavior. 3. Promoting Metastasis: Changes in the ECM composition can facilitate the detachment and migration of cancer cells to distant sites.
