What is ER Stress and How Does it Affect Cancer Cells?
ER stress occurs when the protein-folding capacity of the ER is overwhelmed. This is particularly relevant in cancer because rapidly dividing cells need to produce large amounts of proteins. Persistent ER stress can lead to cell death, but cancer cells often adapt by enhancing their UPR, which helps them survive under stressful conditions. In fact, the UPR is often hijacked by cancer cells to support their growth and survival.
