What Roles Do PDGFs Play in Tumor Microenvironment?
PDGFs contribute significantly to the tumor microenvironment, influencing both cancerous and non-cancerous cells. They recruit and activate stromal cells such as fibroblasts, which in turn secrete extracellular matrix components and additional growth factors that support tumor development. Additionally, PDGFs can modulate immune cell infiltration and function, creating an environment that may either support or inhibit tumor progression depending on the context.
