What are the Challenges in Targeting PDGFs for Cancer Therapy?
Despite the potential benefits, targeting PDGFs in cancer therapy comes with several challenges. One major issue is the redundancy and compensatory mechanisms within the growth factor signaling networks, which can lead to resistance to PDGFR inhibitors. Additionally, the widespread expression of PDGFs and their receptors in normal tissues raises concerns about potential side effects and toxicity. Therefore, ongoing research aims to develop more selective and effective inhibitors with minimal adverse effects.
