What Strategies are Being Used to Overcome MRP1-Mediated Drug Resistance?
Several strategies are being explored to overcome MRP1-mediated drug resistance:
1. MRP1 Inhibitors: Compounds such as verapamil and probenecid have been studied for their ability to inhibit MRP1 function. 2. RNA Interference: Techniques like siRNA and shRNA can be used to knock down MRP1 expression. 3. Gene Editing: The use of CRISPR-Cas9 technology to disrupt the MRP1 gene is another promising approach. 4. Nanotechnology: Nanocarriers can be designed to bypass MRP1-mediated efflux or co-deliver MRP1 inhibitors along with chemotherapeutic drugs.
