What Technologies are Used to Study Methylation Profiles?
Several advanced technologies are used to study methylation profiles in cancer, including:
- Bisulfite Sequencing: Converts unmethylated cytosines to uracil, allowing for the identification of methylation sites. - Methylation-specific PCR (MSP): A technique to detect methylation changes in specific DNA regions. - Illumina MethylationEPIC BeadChip: Offers genome-wide methylation profiling at single CpG resolution. - Whole Genome Bisulfite Sequencing (WGBS): Provides comprehensive methylation mapping across the entire genome.
