What Therapeutic Strategies Target the G2 Phase in Cancer Treatment?
Several cancer therapies aim to exploit the G2 phase. [Chemotherapy](#) agents, such as [cisplatin](#) and [doxorubicin](#), induce DNA damage, overwhelming the cell's repair capacity and triggering cell death. Additionally, inhibitors of checkpoint kinases like [CHK1](#) and [CHK2](#) can prevent cancer cells from arresting in the G2 phase, leading to mitotic catastrophe and cell death.