What types of cancer are associated with Msh2 deficiencies?
Msh2 deficiencies are notably linked to Lynch syndrome, a hereditary condition that significantly increases the risk of several cancers, particularly colorectal cancer. Individuals with mutations in the Msh2 gene have a higher lifetime risk of developing cancers of the colon, endometrium, and other organs. Sporadic cases of MSI-high tumors also occur, often in colorectal, gastric, and endometrial cancers, where Msh2 may be inactivated by mechanisms such as promoter hypermethylation.
