Smoking is the leading cause of lung cancer, responsible for approximately 85% of cases. Besides lung cancer, tobacco use is linked to cancers of the mouth, throat, larynx (voice box), and esophagus. It also increases the risk of cancers in organs like the kidney, bladder, pancreas, and stomach. Even smokeless tobacco, such as chewing tobacco and snuff, can cause cancers of the mouth, throat, and pancreas.