PGD can be used to screen for various hereditary cancer syndromes, particularly those caused by well-defined genetic mutations. Some of the notable hereditary cancer syndromes include:
BRCA1 and BRCA2 mutations, which significantly increase the risk of breast and ovarian cancers. Lynch syndrome, associated with a higher risk of colorectal, endometrial, and other cancers. Familial adenomatous polyposis (FAP), a condition that leads to colorectal cancer if untreated. Li-Fraumeni syndrome, which increases the risk of several types of cancer, including sarcomas, breast cancer, and brain tumors.
