What Types of EGFR Mutations Are Common in Cancer?
There are several types of EGFR mutations that are often seen in cancer: - Exon 19 deletions: These are the most common and involve the deletion of a few amino acids in the receptor. - L858R mutation: A point mutation in exon 21 that substitutes leucine with arginine. - T790M mutation: Often associated with resistance to first-line EGFR inhibitors. - Exon 20 insertions: These are less common but are associated with resistance to many EGFR inhibitors.
