There are two main types of ISH: 1. Fluorescence In Situ Hybridization (FISH) - Uses fluorescent probes to detect DNA or RNA sequences, providing high sensitivity and allowing for the visualization of multiple targets simultaneously. 2. Chromogenic In Situ Hybridization (CISH) - Uses chromogenic substrates to produce a colorimetric signal, which can be observed under a standard light microscope. CISH is often used when fluorescent microscopy is not available.
