Which Cancers are Commonly Associated with Germline Mutations?
Several cancers are associated with germline mutations. These include:
- Breast Cancer: Often associated with BRCA1 and BRCA2 mutations. - Ovarian Cancer: Also linked to BRCA1 and BRCA2 mutations. - Colorectal Cancer: Often associated with mutations in the APC gene and genes involved in Lynch syndrome, such as MLH1 and MSH2. - Prostate Cancer: Linked to BRCA1 and BRCA2 mutations as well as mutations in the HOXB13 gene. - Pancreatic Cancer: Associated with mutations in BRCA2 and other genes like PALB2.
