Several GPCRs have been implicated in different types of cancer. For example, the chemokine receptors such as CXCR4 and CXCR7 are known to play roles in cancer metastasis. Another notable GPCR is the prostaglandin E2 receptor EP2, which is involved in inflammation-associated cancers. The overexpression of receptors like LPA1 and LPA2 has been linked to ovarian and breast cancer progression.
