What challenges are faced in targeting GPCRs in Cancer?
Despite their potential, several challenges exist in targeting GPCRs for cancer therapy:
Complex Signaling: GPCRs can activate multiple pathways, leading to complex and sometimes contradictory cellular outcomes. Redundancy: The presence of multiple GPCRs with overlapping functions can complicate therapeutic targeting. Resistance: Cancer cells can develop resistance to GPCR-targeted therapies, necessitating combination strategies or novel approaches.
