Which Kinesins are Most Relevant in Cancer Research?
Among the kinesin family, KIF11 (also known as Eg5), KIF14, and KIF23 are particularly noteworthy. KIF11 is involved in spindle formation during mitosis and is critical for cell division. Overexpression of KIF14 and KIF23 has been linked with poor prognosis in various cancers such as breast, lung, and colorectal cancer.
