Several MMPs are frequently associated with cancer, including MMP-2, MMP-9, and MMP-14. These enzymes are known to be upregulated in many types of cancers such as breast, prostate, and colorectal cancers. MMP-2 and MMP-9, in particular, are often referred to as gelatinases due to their ability to degrade gelatin and type IV collagen, which are major components of the basement membrane.
