What Are the Current Challenges in Targeting MMPs?
One of the main challenges in targeting MMPs is their dual role in both normal physiological processes and pathological conditions. Broad-spectrum inhibitors often affect multiple MMPs, leading to unwanted side effects. Additionally, the redundancy and compensatory mechanisms within the MMP family complicate the development of effective and specific inhibitors. Future research is focusing on designing selective inhibitors and understanding the context-specific roles of individual MMPs.
