Which MRPs are Most Commonly Associated with Cancer?
Among the various MRPs, MRP1 (ABCC1), MRP2 (ABCC2), and MRP3 (ABCC3) are most commonly associated with cancer. MRP1 is known for its role in exporting antineoplastic drugs such as vinca alkaloids, anthracyclines, and methotrexate. MRP2 and MRP3 also contribute to drug resistance but vary in their substrate specificities and tissue distribution.
