Among the seven known STAT family members (STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, and STAT6), STAT3 and STAT5 are frequently implicated in cancer. Aberrant activation of STAT3 and STAT5 has been observed in various types of cancer, including leukemia, lymphoma, breast cancer, and prostate cancer. These proteins can promote tumorigenesis by enhancing cell proliferation, survival, angiogenesis, and immune evasion.
