The general guidelines for Pap smears vary depending on age and health history. Women aged 21-29 should have a Pap smear every three years. Women aged 30-65 are recommended to have a Pap smear combined with an HPV test (co-testing) every five years, or a Pap smear alone every three years. Women over 65 who have had regular screening in the past 10 years with normal results may no longer need to be screened.