1. Reproducibility: Ensuring that research findings are reproducible is a cornerstone of scientific integrity. Backup samples allow researchers to validate their initial results by re-testing the same samples using different methods or technologies. 2. Technological Advances: The field of cancer research is rapidly evolving. New techniques such as next-generation sequencing, CRISPR, and liquid biopsy are continually being developed. Backup samples enable researchers to apply these cutting-edge techniques to previously collected specimens. 3. Patient-Specific Research: Cancer is a highly heterogeneous disease. Having backup samples allows for personalized research, enabling scientists to study the unique characteristics of each patient's cancer over time. 4. Collaborative Studies: Backup samples can be shared with other research institutions, facilitating multi-center studies and improving the statistical power of research findings.