Backup samples play a significant role in clinical trials. They can be used to:
1. Identify Biomarkers: Backup samples can help identify biomarkers that predict how patients will respond to specific treatments. 2. Monitor Disease Progression: Longitudinal studies using backup samples can provide insights into how cancer evolves over time. 3. Adaptive Trials: In adaptive clinical trials, backup samples can be crucial for making real-time adjustments to the study protocol based on interim findings.