Why are Covalent Inhibitors Important in Cancer Treatment?
Cancer cells often exhibit mutations that lead to the overactivation or dysregulation of certain proteins, making them ideal targets for covalent inhibitors. Because these inhibitors form a permanent bond, they can provide sustained suppression of oncogenic proteins. This is especially critical in cancers driven by kinases, proteases, or other enzymes where transient inhibition might not be sufficient to halt cancer progression.
