Why Are CSF1R Inhibitors Important in Cancer Therapy?
The tumor microenvironment plays a critical role in cancer development and progression. TAMs in particular can suppress the anti-tumor immune response and promote a pro-tumorigenic environment. By targeting CSF1R, these inhibitors can reprogram the tumor microenvironment from a state that supports tumor growth to one that is hostile to cancer cells. This can enhance the efficacy of other therapies, including chemotherapy and immunotherapy.
