What Types of Cancers Are Associated with NF1 Mutations?
NF1 mutations are linked to several types of cancers, including:
Malignant Peripheral Nerve Sheath Tumors (MPNSTs): These are aggressive cancers that arise from the nerve sheath and are commonly associated with NF1 mutations. Gliomas: These are tumors that originate in the glial cells of the brain and spine. People with NF1 are more likely to develop optic pathway gliomas and other types of brain tumors. Breast Cancer: Some studies have shown an increased risk of breast cancer in women with NF1, particularly those under the age of 50. Leukemia: There is an elevated risk of developing certain types of leukemia, such as juvenile myelomonocytic leukemia (JMML), in individuals with NF1.
