Mutations in the NF1 gene can lead to a condition known as Neurofibromatosis Type 1 (NF1), which is characterized by the growth of benign tumors along nerves in the skin, brain, and other parts of the body. However, individuals with NF1 are also at an increased risk of developing malignant tumors, such as malignant peripheral nerve sheath tumors (MPNSTs) and gliomas. The dysfunction of the NF1 gene disrupts the normal regulation of the Ras signaling pathway, leading to increased cell proliferation and tumor development.
