Why are Microsatellites Important in Cancer Research?
Microsatellite analysis is crucial in cancer research because it helps in the detection of microsatellite instability (MSI), a condition of genetic hypermutability resulting from impaired DNA mismatch repair (MMR). MSI is often observed in various types of cancer, including colorectal, endometrial, and gastric cancers. This instability can lead to the accumulation of mutations, which may contribute to cancer progression.
