The aggressiveness of these cancers can be attributed to several factors: - Genetic Mutations: Specific genetic changes in the cancer cells can lead to uncontrollable growth. - Microenvironment: The surrounding tissue and cellular environment can support rapid cancer cell growth and spread. - Resistance to Apoptosis: Aggressive cancers often develop mechanisms to avoid programmed cell death. - Angiogenesis: These cancers can stimulate the formation of new blood vessels to supply the tumor with nutrients and oxygen.