The increased cancer risk associated with shift work is believed to result from the disruption of circadian rhythms. Circadian disruption can affect the production of melatonin, a hormone that regulates sleep and has antioxidant properties. Melatonin suppression due to light exposure at night can lead to an increase in oxidative stress and DNA damage, both of which are linked to cancer development. Additionally, shift work can affect immune function and increase inflammation, further contributing to cancer risk.
