Numerous studies have linked the use of areca nut and betel quid to serious health risks, including various forms of cancer. The International Agency for Research on Cancer (IARC) classifies areca nut and betel quid (with or without tobacco) as Group 1 carcinogens, meaning they are known to cause cancer in humans. Oral cancer, including cancer of the mouth, pharynx, and esophagus, is particularly associated with these substances.