In cancer, the demand for nucleotides is markedly elevated due to the rapid and uncontrolled proliferation of malignant cells. Cancer cells require a continuous supply of DNA and RNA building blocks to sustain their growth. As a rate-limiting enzyme in pyrimidine biosynthesis, ATCase becomes a critical target. Increased ATCase activity has been observed in various types of cancers, making it a potential marker for diagnosis and a target for therapeutic interventions.
