Why is Replication Fork Stalling Important in Cancer?
In cancer cells, replication fork stalling is particularly detrimental because it can result in double-strand breaks (DSBs) and genomic instability. When replication forks stall, they can collapse if not properly resolved, leading to DSBs. Cancer cells often exhibit high levels of replication stress due to rapid proliferation and oncogene activation, making them more susceptible to fork stalling and subsequent genomic instability.
