Why is Understanding Immune Checkpoint Dysregulation Important?
Understanding how immune checkpoints are dysregulated in cancer can lead to the development of new therapeutic strategies. Immunotherapy, particularly immune checkpoint inhibitors like anti-PD-1, anti-PD-L1, and anti-CTLA-4 antibodies, has revolutionized cancer treatment by blocking these checkpoints and thereby reactivating the immune system to attack cancer cells. However, not all patients respond to these therapies, making it essential to understand the underlying mechanisms of checkpoint dysregulation to improve treatment outcomes.
