Cancer cells often have dysregulated cell cycles, allowing them to proliferate uncontrollably. In many cancers, the G2/M checkpoint may be bypassed or dysfunctional. In such scenarios, targeting Wee1 could enhance DNA damage in cancer cells, especially since these cells rely heavily on this checkpoint due to their high replication stress. By inhibiting Wee1, cancer cells can be pushed into premature mitosis, leading to catastrophic cell division and ultimately cell death.
