What is Parathyroid Hormone (PTH)?
Parathyroid hormone (PTH) is a critical peptide hormone produced by the parathyroid glands. It plays a significant role in regulating
calcium levels in the blood, bone metabolism, and ensuring proper functioning of the nervous and muscular systems. PTH increases blood calcium levels by stimulating
osteoclasts, which break down bone and release calcium, and by increasing calcium reabsorption in the kidneys.
These cancers can either secrete PTHrP or cause bone metastases, leading to increased bone resorption and calcium release.
Hydration with intravenous fluids to enhance renal calcium excretion
Use of
bisphosphonates or
denosumab to inhibit bone resorption
Administration of corticosteroids to reduce inflammation and calcium absorption
Addressing the underlying cancer with appropriate oncological treatments
What is the Prognosis for Cancer Patients with Hypercalcemia?
The prognosis for cancer patients with hypercalcemia varies depending on the type and stage of cancer, as well as the effectiveness of treatment. Hypercalcemia can indicate advanced disease and is often associated with a poorer prognosis. However, early detection and prompt management can improve quality of life and outcomes.
Conclusion
Parathyroid hormone (PTH) and its related protein (PTHrP) play crucial roles in the context of cancer, particularly in the development of hypercalcemia. Understanding their interactions with different types of cancers can aid in better diagnosis and management of affected patients, ultimately improving their prognosis and quality of life.
