Are There Any Approved TNF-Based Treatments for Cancer?
Currently, TNF-based treatments for cancer are not widely approved. However, isolated limb perfusion with TNF is a technique used for specific types of cancer, like soft tissue sarcoma and melanoma, where high doses of TNF are delivered directly to a limb to induce tumor necrosis without systemic exposure. This method exploits TNF's ability to induce cell death and improve chemotherapy delivery through increased vascular permeability.
